Antioxidants Special Issue: Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family
نویسندگان
چکیده
منابع مشابه
1-cysteine Peroxiredoxin: a Less Studied Member of Peroxiredoxin in Plants
1-Cysteine Peroxiredoxin (1Cys Prx) is a thiol dependent antioxidative enzyme of molecular weight 20-30 kDa. It contains one catalytic cysteine residue and is found in cytosol. Prx plays an important role in growth, development and dessication tolerance in dormant seeds. It detoxifies H2O2 and various other organic peroxides. It protects lipids, enzymes and DNA against reactive oxygen species. ...
متن کاملPeroxiredoxin 6 in skin carcinogenesis
Non-melanoma skin cancer represents a serious and globally increasing health problem. Therefore, a detailed knowledge on the mechanisms of skin cancer formation is required to develop innovative, efficient and cost-effective strategies for skin cancer prevention and treatment. A major risk factor for cancer formation is oxidative stress, which results from excessive levels of reactive oxygen sp...
متن کاملPREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family
PREX (http://www.csb.wfu.edu/prex/) is a database of currently 3516 peroxiredoxin (Prx or PRDX) protein sequences unambiguously classified into one of six distinct subfamilies. Peroxiredoxins are a diverse and ubiquitous family of highly expressed, cysteine-dependent peroxidases that are important for antioxidant defense and for the regulation of cell signaling pathways in eukaryotes. Subfamily...
متن کاملPeroxiredoxin 6, a novel player in the pathogenesis of diabetes.
Enhanced oxidative stress contributes to the pathogenesis of diabetes and its complications. Peroxiredoxin 6 (PRDX6) is a key regulator of cellular redox balance, with the peculiar ability to neutralize peroxides, peroxynitrite, and phospholipid hydroperoxides. In the current study, we aimed to define the role of PRDX6 in the pathophysiology of type 2 diabetes (T2D) using PRDX6 knockout (-/-) m...
متن کاملIdentification and characterization of the peroxiredoxin gene family in chickens.
Peroxiredoxin (PRX) is a crucial antioxidant protein that protects against endogenously produced peroxides in prokaryotes to eukaryotes. To date, 6 different isoforms have been identified in mammals. In this study, we describe the first members of the PRX protein family to be characterized in Chicken. Through bioinformatics analysis, we observed that at least 4 different classes of PRX protein ...
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2019
ISSN: 2076-3921
DOI: 10.3390/antiox8040107